Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados Genet. Mol. Biol. (1) International Journal of Morphology (1) Autor Harada,Maria Lucia (2) Assumpção,Paulo Pimentel de (1) Burbano,RommelRodríguez (1) Casartelli,Cacilda (1) Leal,Mariana Ferreira (1) Lima,Eleonidas Moura (1) Motta,Fábio José Nascimento (1) Nascimento Borges,Barbara do (1) Rodriguez Burbano,Rommel Mario (1) Rosário Pinheiro,Danilo do (1) Smith,Marilia de Arruda Cardoso (1) Mais... Palavra-chave Gastric cancer (2) Animal model (1) De novo DNA methyltransferases (1) Gene regulation (1) Methylation (1) PTGS2 (1) RUNX3 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2018 (1) 2007 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última COX-2 gene expression and methylation profile in Sapajus apella as an experimental model for gastric adenocarcinoma Genet. Mol. Biol. Rosário Pinheiro,Danilo do; Harada,Maria Lucia; Rodriguez Burbano,Rommel Mario; Nascimento Borges,Barbara do. Abstract Gastric cancer (GC) remains one of the main causes of cancer-related death worldwide. There are two distinct histological types of GC: diffuse and intestinal. The latter is characterized by the presence of pre-neoplastic lesions. One of the most frequently altered enzymes in intestinal GC is COX-2, an important lesion marker. This work aimed to study COX-2 methylation and expression in N-methyl-N-Nitrosurea (MNU)-induced intestinal GC in six Sapajus apella animals. The partial promoter sequence of S. apella COX-2 gene was obtained and used to identify transcription factors and cis-regulatory element binding sites. The COX-2 methylation pattern was assessed using Methylation-Specific PCR (MSP), and expression was analyzed by immunohistochemistry... Tipo: Info:eu-repo/semantics/article Palavras-chave: PTGS2; Gene regulation; Animal model; Gastric cancer. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000300496 Study of Methylation Pattern of de Novo DNA Methyltransferase Genes and its Correlation with DNA Methylation Pattern of RUNX3 in Individuals with Gastric Cancer from Northern Region of Brazil International Journal of Morphology Lima,Eleonidas Moura; Leal,Mariana Ferreira; Motta,Fábio José Nascimento; Assumpção,Paulo Pimentel de; Harada,Maria Lucia; Smith,Marilia de Arruda Cardoso; Burbano,RommelRodríguez; Casartelli,Cacilda. Gastric cancer is the forth malignancy in frequency in the world. In the northern Brazil is the second neoplasia most frequent in males and the third most frequent in females. Genetic and epigenetic alterations are evolved on gastric carcinogenesis and DNA methylation is the epigenetic alteration better studied. We analyzed de novo DNA methyltransferases methylation pattern and its association with RUNX3 gene methylation pattern in Brazilian samples of intestinal-type and diffuse-type of gastric cancer. PCR methylation specific was used to evaluate DNA methylation pattern. Sixty-six samples were studied in this work. Only the gene RUNX3 presented altered methylation pattern, being methylated in 38.5% of gastric cancer intestinal-type samples and in 70% of... Tipo: Journal article Palavras-chave: Methylation; De novo DNA methyltransferases; RUNX3; Gastric cancer. Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400022 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco